Deletional remodeling of c-myc-deregulating chromosomal translocations
✍ Scribed by Kovalchuk, Alexander L; Müller, Jürgen R; Janz, Siegfried
- Book ID
- 110060988
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 435 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A substantial body of evidence indicates that specific chromosomal abnormalities play an important role in the genesis of certain human and animal tumors. In a number of chromosomal translocations, cellular homologues of retroviral transforming genes are located near the breakpoints, suggesting that
We have previously shown that the reciprocal translocation t(6;7) associated with the spontaneous immunocytoma of the Louvain rat (RIC) leads t o the juxtaposition of myc t o the IgH cluster. In I0 of I4 tumors investigated the breakpoints on the myc carrying chromosome were clustered in a I .5 kb r