AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
✍ Scribed by Almudena R. Ramiro; Mila Jankovic; Thomas Eisenreich; Simone Difilippantonio; Selina Chen-Kiang; Masamichi Muramatsu; Tasuku Honjo; André Nussenzweig; Michel C. Nussenzweig
- Book ID
- 116352337
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 320 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0092-8674
No coin nor oath required. For personal study only.
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## Abstract The location of the __Myc__ and immunoglobulin (__Ig__) loci on metacentric Robertsonian (Rb) fusion chromosomes may affect the development of mouse plasmacytomas (Pcts) by changing the probability with which chromosomal __Myc__–__Ig__ translocations occur. To test this hypothesis, we i
## Abstract The DCPC 21 plasmocytoma lacks any of the MPC‐associated chromosomal translocations. However, the __c‐myc__ gene has been transposed to the IgH locus on chromorome 12 by an Ig switch‐region‐mediated recombination mechanism. DNA sequencing analysis, further, revealed that this recombinat