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Deletion ΔF508 and clinical expression of cystic fibrosis-related liver disease

✍ Scribed by M. De Arce; S. O'Brien; J. Hegarty; S. M. O'Mahoney; S. M. Cashman; A. Martinez; M. Delgado; M. X. FitzGerald


Book ID
115090338
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
159 KB
Volume
42
Category
Article
ISSN
0009-9163

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Preimplantation genetic diagnosis (PGD) was attempted in 12 couples in whom both parents carry the common AF508 deletion causing cystic fibrosis (CF). In vitro fertilization (IVF) was followed by cleavage stage biopsy on days 2 and 3 and removal of one or two cells for genetic analysis by nested pol