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Cystic fibrosis: Relationship between clinical status and F508 deletion

โœ Scribed by Preston W. Campbell III; John A. Phillips III; M.R.S. Krishnamani; Kimberly J. Maness; Thomas A. Hazinski


Book ID
117162269
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
442 KB
Volume
118
Category
Article
ISSN
1097-6833

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Preimplantation genetic diagnosis (PGD) was attempted in 12 couples in whom both parents carry the common AF508 deletion causing cystic fibrosis (CF). In vitro fertilization (IVF) was followed by cleavage stage biopsy on days 2 and 3 and removal of one or two cells for genetic analysis by nested pol