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Deletion of chromosome arm 1p in a merkel cell carcinoma (MCC)

✍ Scribed by Dr. Zenon Gibas; Susan Weil; Sing-Tsung Chen; Peter A. McCue

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 376 KB
Volume: 9
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870090310

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✦ Synopsis

A case of neuroendocrine skin carcinoma (Merkel cell carcinoma) with a deletion of the short arm of chromosome I (I p) as the sole chromosomal abnormality was examined. The tumor originated in the skin of the left knee of a 67-year-old man. Histopathologic study showed an undifferentiated small cell tumor which expressed neuron-specific enolase, chromogranin, and cytokeratin (CAM 5.2). Cytogenetic analysis of a lymph node metastasis from the groin showed a pseudodiploid cell population with a deletion of the short arm of chromosome I as the only abnormality: 46,XY,del( l)(p36. I). In situ hybridization with the D I 2 2 probe specific for the terminal band of I p confirmed the terminal deletion. This is the first case of Merkel cell carcinoma in which only one chromosomal abnormality has been observed. Loss of the terminal portion of Ip suggests that a tumor supressor gene on I p plays a role in the pathogenesis of Merkel cell carcinoma. Genes Chrom Cancer 9:2 16-220 (1994).

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