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Deletion of 3p25→pter in a primary follicular thyroid carcinoma and its metastasis

✍ Scribed by Lúcia Roque; Prof. Sérgio Castedo; Ana Clode; Jorge Soares

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
310 KB
Volume
8
Category
Article
ISSN
1045-2257

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✦ Synopsis

We report the cytogenetic analysis of a follicular thyroid carcinoma and its bone metastasis. Both lesions had identical chromosomal abnormalities, with a der(3)t(2;3)(q I3;p25) as the most likely primary clonal alteration. Our findings corroborate previous observations of frequent 3p deletions in thyroid follicular carcinomas and suggest that the minimal chromosomal region of loss in these tumors is 3p25-pter.

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