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Delayed onset of active experimental autoimmune encephalomyelitis (EAE) in mice deficient in interleukin-1β converting enzyme (ICE)

✍ Scribed by L.J. Robichaud; S.M. Lotarski; S.A. Linn; S. Banerjee; B. Shivers; P.A. Boxer


Book ID
114138609
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
132 KB
Volume
90
Category
Article
ISSN
0165-5728

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Interleukin-1b converting enzyme (ICE) processes the inactive proIL-1b to the proinflammatory mature IL-1b. ICE belongs to a family of cysteine proteases that have been implicated in apoptosis. To address the biological functions of ICE, we generated ICE-deficient mice through gene targeting technol