✦ LIBER ✦

Delayed hypersensitivity reactions of cancer patients to antigens on lymphoid cell lines

✍ Scribed by P. H. Levine; J. H. C. Ho; F. Nkrumah; P. Periman; N. Mourali; G. Cannon; M. B. Middleton; I. V. Perkins; R. Herberman

Publisher: John Wiley and Sons
Year: 1978
Tongue: French
Weight: 543 KB
Volume: 22
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910220406

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Four‐hundred and fifty niné cancer patients were skin tested with extracts from five lymphoid cell lines. More than 50% of patients with lymphoma had positive skin tests with the extracts prepared from the cell line derived from Burkitt's lymphoma (BL) and more than 50% of nasopharyngeal carcinoma (NPC) patients reacted to the NPC‐derived cell line extracts. Although the significant association between patient diagnosis and origin of cell lines suggested that tumor‐associated antigens were responsible for the pattern of delayed hyper‐sensitivity, problems in standardization of antigen potency and non‐specificity need to be resolved before this in vivo assay achieves its full potential.

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