Specific and aspecific immune responsiveness in lung cancer patients: Cutaneous delayed hypersensitivity reactions to a lung cancer-associated antigen
✍ Scribed by Ercole Sega; Marcella Mottolese; Paola Cordiali-Fei; Gennaro Citro; Sergio Colizza; Annamaria Alcione; Manolo Di Paola
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 661 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-4790
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✦ Synopsis
Abstract
The ability of a lung cancer‐associated antigen (LCAA) to provoke specific cutaneous delayed‐hypersensitivity reactions has been studied on a group of 59 lung cancer patients. Biological activity of LCAA, monitored by skin testing, was demonstrated in 32% (17 of 53) of lung cancer patients, in 48.0% with limited disease, and in 17.2% with extensive disease.
All the responders were in the group of normal reactors to standard recall antigens, if three antigens were used (PPDSK‐SD, candida). No correlation was found between biological activity of LCAA and level of immunocompetence evaluated by lymphocyte‐blastic transformation with PHA and count of rosette E‐forming cells.
These studies on the capacity to evoke specific DTH reactions in lung‐cancer patients will be extended to the use of assays in vitro in the perspective of a more significant evaluation of immunocompetence levels.