An amorphous matrix comprised of sugar molecules is used as excipient and stabilizing agent for labile ingredients in the pharmaceutical industry. The amorphous sugar matrix is often compressed into a tablet form to reduce the volume and improve handling. Herein, the effect of compression on the cry
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Delayed crystallization of amorphous sucrose in humidified freeze dried model systems
β Scribed by HECTOR A. ISLESIAS; JORGE CHIRIFE
- Book ID
- 108803030
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 295 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0950-5423
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Phase separation in amorphous freeze-dried proteins systems is speculated to occur, but limitations in methods of detection have hindered progress in identifying and studying this phenomenon. We present here preliminary results obtained on model two-component protein-stabilizer systems that illustra