Previous studies have established that the selective precipitation of a less soluble buffer component during freezing can induce a significant pH shift in the freeze concentrate. During freezing of sodium phosphate solutions, crystallization of the disodium salt can produce a pH decrease as great as
Glycine Crystallization in Frozen and Freeze-dried Systems: Effect of pH and Buffer Concentration
✍ Scribed by Dushyant B. Varshney; Satyendra Kumar; Evgenyi Y. Shalaev; Prakash Sundaramurthi; Shin-Woong Kang; Larry A. Gatlin; Raj Suryanarayanan
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 969 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0724-8741
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Selective crystallization of buffer components in frozen solutions is known to cause pronounced pH shifts. Our objective was to study the crystallization behavior and the consequent pH shift in frozen aqueous carboxylic acid buffers. Aqueous carboxylic acid buffers were cooled to -25°C and the pH of
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