## Abstract Estradiol levels in breast tumors from postβmenopausal women are similar to those in preβmenopausal women even though plasma estrogens are much lower after the menopause. __In situ__ estrogen production by the tumor provides a potential means of maintaining high estradiol levels in post
Dehydroepiandrosterone and estrone 17-ketosteroid reductases in MCF-7 human breast cancer cells
β Scribed by John H. MacIndoe; Marilyn Hinkhouse; Gayle Woods
- Publisher
- Springer US
- Year
- 1990
- Tongue
- English
- Weight
- 814 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
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## Abstract Direct evidence was obtained for __de novo__ synthesis of AFP by MCFβ7 human breast cancer cells __per se.__ Synthesis was demonstrated by Lβ^14^Cβleucine and Lβ^35^Sβmethionine incorporation into immunochemically isolated AFP, and confirmed by radioimmunodiffusion and radioimmunoelectr
A study of MCF-7 human breast cancer cells was undertaken to ascertain the degree of apoptosis induction by paclitaxel and if the induction of apoptosis could be enhanced by caffeine. Paclitaxel (0-20 ng/ml) caused concentration-dependent increases in morphologically identifiable apoptotic cells (up