Dehydration of Ethyl 2-Benzyl-3-hydroxy-2-methylpentanoate
β Scribed by HANLEY, JAMES R.; KILLAM, H. SCOTT; LANYON, ROBERT D.; MacKENZIE, SCOTT
- Book ID
- 121872093
- Publisher
- American Chemical Society
- Year
- 1958
- Tongue
- English
- Weight
- 539 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-3263
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Synthesis of (S)-2-Ethyl-2-methylpentanoic Acid from the Formate Ester of (S) Ethyl 2-Formyl-3-hydroxy-2-methylpropionate. -The key steps in the synthesis of the title compound (X) are olefinations of the aldehydes (I) and (VII). -(FRONZA, G.;
The title compound, C 25 H 40 N 2 O 5 , was synthesized in 55.9% yield by condensation of N-methyl-l-leucine benzyl ester toluene sulfonic acid with tert-butoxycarbonyl-l-leucine at 273 K and its crystal structure determined. The dipeptide derivative conjugates through the amide linkage and includes