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Degradation kinetics and isomerization of cefdinir, a new oral cephalosporin, in aqueous solution. 1

โœ Scribed by Yoshihiko Okamoto; Kuniko Kiriyama; Yoshihiro Namiki; Junichi Matsushita; Mamoru Fujioka; Tsutomu Yasuda

Book ID
109388479
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
453 KB
Volume
85
Category
Article
ISSN
0022-3549

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Degradation kinetics and mechanisms of a
Degradation kinetics and mechanisms of a new cephalosporin, cefixime, in aqueous solution
โœ Yoshihiro Namiki; Toyoshige Tanabe; Toshimitsu Kobayashi; Junko Tanabe; Yoshiko ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 703 KB

Hydrolysis of cefixime in buffer solutions (pH 1-9) at 25 "C and a constant ionic strength of 0.3 was investigated using ion-pair reversed-phase HPLC. Hydrolysis rates followed pseudo first-order kinetics; the rate of hydrolysis of cefixime was very slow at pH 4-7, slightly faster at lower pH, and q