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Degradation kinetics in aqueous solution of cefotaxime sodium, a third-generation cephalosporin

โœ Scribed by H. Fabre; N. Hussam Eddine; G. Berge

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
657 KB
Volume
73
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES

Kinetics and mechanism of degradation of
Kinetics and mechanism of degradation of cefotaxime sodium in aqueous solution
โœ S. M. Berge; N. L. Henderson; M. J. Frank ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 481 KB ๐Ÿ‘ 2 views

The degradation kinetics and mechanism of a potent new cephalosporin, cefotaxime sodium, in aqueous solution were investigated at pH 0-10 at 25 degrees and an ionic strength of 0.5. The degradation rates were determined by high-pressure liquid chromatography and were observed to follow pseudo first-

Degradation kinetics and mechanisms of a
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Hydrolysis of cefixime in buffer solutions (pH 1-9) at 25 "C and a constant ionic strength of 0.3 was investigated using ion-pair reversed-phase HPLC. Hydrolysis rates followed pseudo first-order kinetics; the rate of hydrolysis of cefixime was very slow at pH 4-7, slightly faster at lower pH, and q