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Degradation Behavior of Covalently Cross-Linked Poly(aldehyde guluronate) Hydrogels

✍ Scribed by Lee, Kuen Yong; Bouhadir, Kamal H.; Mooney, David J.

Book ID
120337882
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
162 KB
Volume
33
Category
Article
ISSN
0024-9297

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We have incorporated daunomycin, an antineoplastic agent, into a biodegradable hydrogel through a labile covalent bond. In brief, sodium alginate was chemically broken down to low molecular weight and followed by oxidation to prepare poly-(aldehyde guluronate). Adipic dihydrazide was used to incorpo