𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Sustained and controlled release of daunomycin from cross-linked poly(aldehyde guluronate) hydrogels

✍ Scribed by Kamal H. Bouhadir; Geneveive M. Kruger; Kuen Yong Lee; David J. Mooney

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
250 KB
Volume
89
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

We have incorporated daunomycin, an antineoplastic agent, into a biodegradable hydrogel through a labile covalent bond. In brief, sodium alginate was chemically broken down to low molecular weight and followed by oxidation to prepare poly-(aldehyde guluronate). Adipic dihydrazide was used to incorporate the drug into the polymer backbone and cross-link the polymer to form hydrogels. Daunomycin can be released from the hydrogel after the hydrolysis of the covalent linkage between the drug and the polymer. A wide range of release profiles of daunomycin (e.g., from 2 days to 6 weeks) has been achieved using these materials, and the biological activity of the released daunomycin was maintained.

📜 SIMILAR VOLUMES

Studies on the release of ibuprofen from
Studies on the release of ibuprofen from Al3+ ion cross-linked homopolymeric and interpenetrating network hydrogel beads of carboxymethyl xanthan and sodium alginate
✍ Rajat Ray; Siddhartha Maity; Sanchita Mandal; Tapan Kumar Chatterjee; Biswanath 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 333 KB 👁 2 views

## Abstract Homopolymeric and interpenetrating network (IPN) hydrogel beads of ibuprofen (IBP), a nonsteroidal anti‐inflammatory drug, were prepared using carboxymethyl xanthan and sodium alginate as polymers and AlCl~3~ as a cross‐linking agent. Formation of IPN structure was examined using FTIR a