In a family with a constitutional translocation t(3;6), the oldest member carrying the translocation had developed multiple nonpapillary renal cell carcinomas (RCCs). The translocation breakpoint was positioned between 3p I 3 and 3p 14. I. This is close t o the region in which a t(3;8) breakpoint ha
Defining the positions of the constitutive t(3,8) and t(3,6) breakpoints that occur in families with renal cell carcinoma
โ Scribed by Anneke van der Veen; Anke van den Berg; Miriam Hulsbeek; Klaas Kok; Gyula Kovacs; Harry Drabkin; Charles Buys
- Book ID
- 119106313
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 98 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Studying the molecular basis of familial renal cell carcinoma (RCC) has allowed identification of novel RCC genes involved in the pathogenesis of both inherited and sporadic RCC. We describe a constitutional balanced t(3;8)(p14;q24.1) translocation found in a brother and sister with bil
In a loss of heterozygosity analysis of 3p, we examined 44 sporadic cases of renal cell carcinoma (RCC) and matched normal tissue with 18 markers distributed over the whole p-arm. The majority of these markers clustered in three regions that have been suggested t o be involved in the development of