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Defining the positions of the constitutive t(3,8) and t(3,6) breakpoints that occur in families with renal cell carcinoma

โœ Scribed by Anneke van der Veen; Anke van den Berg; Miriam Hulsbeek; Klaas Kok; Gyula Kovacs; Harry Drabkin; Charles Buys


Book ID
119106313
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
98 KB
Volume
77
Category
Article
ISSN
0165-4608

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๐Ÿ“œ SIMILAR VOLUMES


Defining the position of the breakpoint
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In a family with a constitutional translocation t(3;6), the oldest member carrying the translocation had developed multiple nonpapillary renal cell carcinomas (RCCs). The translocation breakpoint was positioned between 3p I 3 and 3p 14. I. This is close t o the region in which a t(3;8) breakpoint ha

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## Abstract Studying the molecular basis of familial renal cell carcinoma (RCC) has allowed identification of novel RCC genes involved in the pathogenesis of both inherited and sporadic RCC. We describe a constitutional balanced t(3;8)(p14;q24.1) translocation found in a brother and sister with bil

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