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Defining the hematopoietic stem cell niche: The chicken and the egg conundrum

✍ Scribed by Sofie Singbrant; Maria Askmyr; Louise E. Purton; Carl R. Walkley

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
209 KB
Volume
112
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the cellular composition of the niche, is it possible to manipulate any given cell lineage in vivo without impacting, knowingly or unknowingly, on those that remain?

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