## Abstract The enormous regenerative capacity of the blood system to sustain functionally mature cells are generated from highly proliferative, shortโlived progenitors, which in turn arise from a rare population of pluripotent and selfโrenewing hematopoietic stem cells (HSC). In the bone marrow, t
A new bone to pick: osteoblasts and the haematopoietic stem-cell niche
โ Scribed by Jiang Zhu; Stephen G. Emerson
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 112 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
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Osteoblasts (OBs) exert a prominent regulatory effect on hematopoietic stem cells (HSCs). We evaluated the difference in hematopoietic expansion and function in response to co-culture with OBs at various stages of development. Murine calvarial OBs were seeded directly (fresh) or cultured for 1, 2, o
## Abstract Bone marrowโderived mesenchymal stem cells (BMDMSCs) have been targeted for use in enhancement of bone healing; and their osteogenic potential may be further augmented by genes encoding bone morphogenetic proteins (BMP's). The purpose of this study was to compare the effect of genetic m