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Deficient DNA repair in the human progeroid disorder, Werner syndrome

โœ Scribed by Vilhelm A. Bohr


Book ID
113808653
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
158 KB
Volume
577
Category
Article
ISSN
0027-5107

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DNA mismatch repair (MMR) is essential for genome stability and inheritance of a mutated MMR gene, most frequently MSH2 or MLH1, results in cancer predisposition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC). Tumors that arise through MMR deficiency show instability at