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Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy

✍ Scribed by Sander M. Botter; Michel Zar; Gerjo J. V. M van Osch; Harry van Steeg; Martijn E. T. Dollé; Jan H. J. Hoeijmakers; Harrie Weinans; Johannes P. T. M. van Leeuwen

Book ID
106575533
Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
700 KB
Volume
33
Category
Article
ISSN
0161-9152

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## Abstract Germline mutations in DNA mismatch repair genes underlie one of the most common hereditary cancer predisposition syndromes known in humans, hereditary nonpolyposis colorectal cancer (HNPCC). Defects of the DNA mismatch repair system are also prevalent in sporadic colorectal cancers. The