NFATc3 deficiency may contribute to the
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Hoyun Lee; Luc Chouinard; Michel Bonin; Robin N. Michel
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Article
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2005
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John Wiley and Sons
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English
⚖ 131 KB
The nuclear transcription factor of activated T cells (NFAT) suggested to be a tumor suppressor. Here we report that two out of three NFATc3À/À and two in four NFATc3þ/À female mice developed aggressive mammary adenocarcinoma by 12.5 and 16 mo of age, respectively, with no occurrences in age-matched