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Defective thymine dimer excision in radiation-sensitive mutants rad10 and rad16 of Saccharomyces cerevisiae

✍ Scribed by Prakash, Louise

Publisher: Springer
Year: 1977
Tongue: English
Weight: 384 KB
Volume: 152
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00268808

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✦ Synopsis

Two rad mutants of yeast, rad10 and rad16, are shown to be defective in the removal of UV-induced pyrimidine dimers since DNAs obtained from irradiated cells following a post-irradiation incubation in the dark still retain UV-endonuclease-sensitive sites. Both rad10 and rad16 mutants are in the same pathway of excision-repair as the rad1, rad2, rad3 and rad4 mutants.

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