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Defective Repair of Ionizing Radiation Damage in Cockayne's Syndrome and Xeroderma Pigmentosum Group G

โœ Scribed by PRISCILLA K. COOPER; STEVEN A. LEADON


Book ID
119871218
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
173 KB
Volume
726
Category
Article
ISSN
0890-6564

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Inhibition of the gap-filling, polymerizing step of excision repair by 1-0-D-arabinofuranosylcytosine (ara-C) after irradiation with ultraviolet light in human diploid fibroblasts resulted in the formation of persistent DNA strand breaks in G,, G,, and plateau phase cells, but not in S phase cells.