✦ LIBER ✦
Sensitivity of excision repair in normal human, xeroderma pigmentosum variant and Cockayne's syndrome fibroblasts to inhibition by cytosine arabinoside
✍ Scribed by James E. Cleaver
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 902 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
✦ Synopsis
Inhibition of the gap-filling, polymerizing step of excision repair by 1-0-D-arabinofuranosylcytosine (ara-C) after irradiation with ultraviolet light in human diploid fibroblasts resulted in the formation of persistent DNA strand breaks in G,, G,, and plateau phase cells, but not in S phase cells. Addition of hydroxyurea to ara-C resulted in partial inhibition of repair in S phase cells.