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Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts

✍ Scribed by Stefania Bergamaschi; Giuliano Binetti; Stefano Govoni; William C. Wetsel; Fiorenzo Battaini; Marco Trabucchi; Angelo Bianchetti; Marco Racchi

Book ID: 116125220
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 531 KB
Volume: 201
Category: Article
ISSN: 0304-3940
DOI: 10.1016/0304-3940(95)12168-4

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Both neural and nonneural human tissues from patients with or without Alzheimer's disease (AD) were surveyed to detect the presence of the P-amyloid protein and its precursors. This was accomplished using polyclonal and monoclonal antibodies to epitopes in the 695 amino acid long p-APP (i.e., P-APPm