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Defective oxidative metabolism of myodystrophic skeletal muscle mitochondria

✍ Scribed by Dr. C. P. Lee; M. E. Martens; L. Jankulovska; M. A. Neymark

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
731 KB
Volume
2
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

A small‐scale procedure for preparing tightly coupled intact skeletal muscle mitochondria from myodystrophic (myd/myd) mice is described. Mitochondrial preparations derived from heart, liver, and skeletal muscle of myd/myd and their littermate (+/?) controls are characterized with respect to their cytochrome content and their oxidative and phosphorylative capacities. Our data indicate that there is an impairment in the NADH CoQ region of the respiratory chain of myodystrophic skeletal muscle mitochondria. Both heart and liver mitochondria of myd/myd exhibited normal activities of respiratory chain‐linked oxidative phosphorylation.

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