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Defective neutrophil chemotaxis and bactericidal power in a child with hyperimmunoglobulinemia E

✍ Scribed by F. Patrone; F. Dallegri; A. Rebora

Publisher
Springer
Year
1979
Tongue
English
Weight
398 KB
Volume
130
Category
Article
ISSN
0340-6997

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✦ Synopsis

An 11-year-old boy with a life-long history of atopic-like dermatitis and recurrent staphylococcal abscesses was found to have defective neutrophil chemotaxis, impaired-T-lymphocyte functions, hyperimmunoglobulinemia E, and delayed neutrophil bactericidal power. This latter defect has never been found in such patients. The patient's mother revealed a panhypogammaglobulinemia, while his sister and maternal grandmother who had repeated infections were immunologically normal.

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A new defect of chemotaxis and random motility of polymorphonuclear leukocytes is described in a patient with severe recurrent bacterial infections since early childhood. This defect seems to be intrinsic to the cells. The patient's plasma did not contain an inhibitor of chemotaxis. Addition of plas