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Defective Expression of Bruton's Tyrosine Kinase in Acute Lymphoblastic Leukemia

✍ Scribed by Goodman, Patricia A.; Wood, Carla M.; Vassilev, Alexei O.; Mao, Chen; Uckun, Fatih M.


Book ID
120506481
Publisher
Informa plc
Year
2003
Tongue
English
Weight
297 KB
Volume
44
Category
Article
ISSN
1042-8194

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Mutations in BrutonΒ΄s tyrosine kinase (BTK) gene result in X linked agammaglobulinemia (XLA). Using Single Strand Conformation Polymorphism (SSCP) followed by direct sequencing 21 mutations were found in 27 patients with an XLA phenotype from 21 unrelated families. We identified 13 novel and 8 known