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Defective DNA repair in Fanconi's anaemia

✍ Scribed by POON, PETER K.; O'BRIEN, RICHARD L.; PARKER, JOHN W.


Book ID
109692083
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
380 KB
Volume
250
Category
Article
ISSN
0028-0836

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The activity of DNA topoisomerase I(DNA nicking-closing enzyme) was analysed in cytoplasmic and nuclear extracts of six independently derived Fanconi and four normal fibroblast cell lines. In all experiments the total cellular activity was predominantly found in the nuclear extracts (88-100%). In ad