Defective chemotaxis and adherance in granulocytes from chronic myeloid leukemia (CML) patients
β Scribed by Pervin N. Anklesaria; Suresh H. Advani; Avinash N. Bhisey
- Book ID
- 113238456
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 876 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0145-2126
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Binding of chemoattractant to polymorphonuclear leukocytes (PMNL) triggers a series of events like polymerization of actin and tubulin, orientation of cells, chemotaxis, increase in fluid pinocytosis and phagocytosis, and stimulation of microbicidal pathways which includes lysosomal degranulation an
Chronic myeloid leukemia (CML), a hematopoietic stem cell disorder, is characterized by the presence of Philadelphia chromosome (Ph1). Earlier studies have shown that various functions, such as chemotaxis, fluid phase pinocytosis, phagocytosis, and degranulation in response to chemotactic peptide fo