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Defective caspase-3 relocalization in non-small cell lung carcinoma

✍ Scribed by Joseph, Bertrand; Ekedahl, Jessica; Lewensohn, Rolf; Marchetti, Philippe; Formstecher, Pierre; Zhivotovsky, Boris


Book ID
110064685
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
734 KB
Volume
20
Category
Article
ISSN
0950-9232

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We analyzed a set of 103 non-small cell lung carcinomas (NSCLCs) for caspase-3, -6 and -8 expression and apoptosis. Additionally, the expression of bcl-2, bax and p53 were studied. Caspase-3 positivity appeared as diffuse, cytoplasmic staining and was restricted to the tumor area. In contrast, the i