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Decreased Synthesis of Glycosphingolipids in Cells Lacking Vimentin Intermediate Filaments

โœ Scribed by Baiba K. Gillard; Rhonda Clement; Emma Colucci-Guyon; Charles Babinet; Gunter Schwarzmann; Takao Taki; Takashi Kasama; Donald M. Marcus


Book ID
115603014
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
213 KB
Volume
242
Category
Article
ISSN
0014-4827

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Taxol, a microtubule stabilizing agent, has been extensively investigated for its antitumor activity. The cytotoxic effect of taxol is generally attributed to its antimicrotubule activity and is believed to be cell cycle dependent. Herein, we report that taxol induces hyperphosphorylation and reorga