Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas
✍ Scribed by Diez de Medina, Sixtina Gil; Chopin, Dominique; Marjou, Ahmed El; Delouvée, Annie; LaRochelle, William J; Hoznek, Andràs; Abbou, Claude; Aaronson, Stuart A; Thiery, Jean Paul; Radvanyi, François
- Book ID
- 110060491
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 514 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0950-9232
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## Background: Angiogenesis is a prerequisite to cancer growth and metastasis and is induced by a variety of angiogenic factors, including platelet-derived endothelial cell growth factor (pdecgf). the authors investigated the expression of pdecgf in 58 initial primary bladder carcinomas. ## Method
factor (FGF) family. KGF is a stromally derived, paracrine growth factor specifically mitogenic for a variety of epithelial cells. The KGF receptor (KGFR), which is a splice Tuulikki Nyman, M.A. Martti A ¨mma ¨la ¨, M.D. variant of the FGF receptor-2 (FGFR-2)/bek gene, is expressed only in epitheli