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Decreased expression of DCC mRNA in gastric and colorectal cancer

โœ Scribed by Masafumi Kataoka; Takahiro Okabayashi; Kunzo Orita

Book ID
112290297
Publisher
Springer
Year
1995
Tongue
English
Weight
800 KB
Volume
25
Category
Article
ISSN
1436-2813

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The mRNA expression levels of DCC gene, which is cloned from the deleted region of chromosome 18q in colorectal cancers and thought to be a tumor-suppressor gene, was evaluated in tissue specimens surgically resected from patients with colorectal cancer by RT-PCR. This method was chosen as the expre

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Loss of heterozygosity (LOH) or decreased expression of the deleted in colorectal cancer (DCC) gene, a candidate tumor suppressor gene, has been suggested to correlate with progression in several types of tumors. In human gastric cancers, although DCC LOH has been reported to be frequent in expandin