Deconvolution method for accurate determination of overlapping peak areas in chromatograms
β Scribed by Thomas J. Nelson
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 694 KB
- Volume
- 587
- Category
- Article
- ISSN
- 1873-3778
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π SIMILAR VOLUMES
The point-area method for deconvolution derives a "staircase" input function which, when convolved onto the characteristic function, gives an output function coincidental with the given output data points. The area--area method for deconvolution is shown to be erroneous.
A simple method is presented for peak area correction of overlapping peaks. This correction is necessary for the normal approach of dealing with overlapping peaks by a vertical line at the valley point. The relative area errors caused by this vertical line are calculated as the correction factors in