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Decitabine in Myelodysplastic Syndromes

โœ Scribed by Hussain I. Saba; Pierre W. Wijermans

Book ID
117821878
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
775 KB
Volume
42
Category
Article
ISSN
1532-8686

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## Abstract ## BACKGROUND Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.