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Improving patient outcomes with decitabine therapy for myelodysplastic syndromes

✍ Scribed by Jan Davisson

Book ID
118627923
Publisher
Frontline Medical Communications, Inc.
Year
2008
Tongue
English
Weight
83 KB
Volume
5
Category
Article
ISSN
1548-5315

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## Abstract ## BACKGROUND Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.