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Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors

✍ Scribed by Kehl Markley; Samuel Gurin

Book ID
115788470
Publisher
Elsevier Science
Year
1959
Weight
174 KB
Volume
31
Category
Article
ISSN
0006-3002

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The biosynthesis of derivatives of allyl
The biosynthesis of derivatives of allylic alcohols from [2-14C] mevalonate in liver enzyme preparations and their relation to synthesis of squalene
✍ G. PopjΓ‘k πŸ“‚ Article πŸ“… 1959 πŸ› Elsevier Science 🌐 French βš– 497 KB

STUDIES on the enzymic synthesis of squalene from mevalonic acid (3:5dihydroxy-j-methylpentanoic acid) in yeast extracts have revealed a number of nei intermediates. 5-Phosphomevalonate,1'2'3 54iphosphomevalonate and 3-methylbut-J-en-l;yl. pyrophosphate (isopentenyl pyrophosphate) 4,5,6 have been re