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Dealkylation of N(3)-methyl-6-amino-3-azabicyclo[3.1.0]hexane derivatives

✍ Scribed by Karin Fröhlich; Rolf Wagemann; Elmar Vilsmaier


Book ID
108379101
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
799 KB
Volume
54
Category
Article
ISSN
0040-4020

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The cyano moiety in dibenzylamino-3-azabicyclo[3.l.0]hexane-6-carbonitriles 14c, d can be removed reductively by alkali metals: sodium in liquid ammonia at low temperatures causes a reaction with retention of configuration whilst fithium in an ethylamine -ammonia mixture at 0°C leads predominantly t