Sporadic breast carcinomas demonstrate microsatellite instability, reflecting the presence of DNA mismatch repair-deficient cells, in about one fourth of cases at the time of diagnosis. Loss of DNA mismatch repair has been reported to result in resistance not only to cisplatin and alkylating agents
Deadweight loss of bacterial resistance due to overtreatment
β Scribed by Elamin H. Elbasha
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 187 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1057-9230
- DOI
- 10.1002/hec.702
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β¦ Synopsis
Abstract
Widespread use of antibiotics is considered the major driving force behind the development of antibiotic resistance. The benefits of exceeding the welfareβmaximizing level of antibiotic use are below the costs of resistance created by this excess quantity of antibiotics used, thereby resulting in a welfare deadweight loss. This paper uses a simple economic model to examine the theoretical and empirical aspects of the welfare loss generated by resistance and analyzes its policy implications. The annual deadweight loss associated with outpatient prescriptions for amoxicillin in the United States is estimated at $225 million. Published in 2002 by John Wiley & Sons, Ltd.
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