Selective nitration of paclitaxel and re
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Koppaka V. Rao; James H. Johnson Jr.
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Article
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1998
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Elsevier Science
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French
β 214 KB
Paclitaxcl and some of its natural analogues are readily converted to their respective nitrate esters when reacted with nitric acid in acetic anhydride at 25 Β° C in 30 minutes. Under milder conditions. partially esterified products can be prepared. The regioselectivity of these partial nitrations is