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De Novo Synthesis of Uronic Acid Building Blocks for Assembly of Heparin Oligosaccharides

✍ Scribed by Alexander Adibekian; Pascal Bindschädler; Mattie S. M. Timmer; Christian Noti; Nina Schützenmeister; Peter H. Seeberger

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 379 KB
Volume: 13
Category: Article
ISSN: 0947-6539
DOI: 10.1002/chem.200700141

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## Abstract The synthesis of the four building blocks used for the preparation of hexitol nucleic acids were optimized. The nucleoside analogues with a purine base moiety are best prepared by a nucleophilic substitution reaction, whereas the pyrimidine nucleosides can best be obtained using Mitsuno