De novo purine and pyrimidine biosynthesis during thymocyte concanavalin A stimulation
✍ Scribed by Laure Thuillier; Florianne Garreau; Michèle Hamet; Pierre Cartier
- Book ID
- 115891563
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 679 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0014-4827
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## Abstract Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5′‐phosphate (UMP) synthase. It has been previously shown in concanavalin A (con A)‐stimulated guinea pig lymphocytes (23) that pyrazo
Gas chromatographic/mass spectrometric methods for the measurement of the flux through the de novo pyrimidine biosynthetic pathway by quantitating the incorporation of [13C]bicarbonate and 13CO2 into the uracil nucleotide pool in L1210 tumors are reported. Simultaneous measurements of the incorporat