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Effects of acivicin and pala, singly and in combination, on de novo pyrimidine biosynthesis

✍ Scribed by Thomas W. Kensler; Hiremagalur N. Jayaram; David A. Cooney


Book ID
118371932
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
711 KB
Volume
20
Category
Article
ISSN
0065-2571

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Alteration in de novo pyrimidine biosynt
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## Abstract Pyrazofurin, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5′‐phosphate (UMP) synthase. It has been previously shown in concanavalin A (con A)‐stimulated guinea pig lymphocytes (23) that pyrazo