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De novo lipogenesis in health and disease

✍ Scribed by Ameer, Fatima; Scandiuzzi, Lisa; Hasnain, Shahida; Kalbacher, Hubert; Zaidi, Nousheen

Book ID
123327514
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
590 KB
Volume
63
Category
Article
ISSN
1532-8600

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## Abstract Cancers express high levels of fatty acid synthase (FAS) from which they derive fatty acids for membrane biosynthesis to sustain cell proliferation. How cancer cells coordinate __de novo__ lipogenesis and proliferation has not been investigated. Transcription factors Sp1, Sp3 and Sp4 ar