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De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

✍ Scribed by Eissing, Leah; Scherer, Thomas; Tödter, Klaus; Knippschild, Uwe; Greve, Jan Willem; Buurman, Wim A.; Pinnschmidt, Hans O.; Rensen, Sander S.; Wolf, Anna M.; Bartelt, Alexander; Heeren, Joerg; Buettner, Christoph; Scheja, Ludger


Book ID
120311171
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
486 KB
Volume
4
Category
Article
ISSN
2041-1723

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## Aspartyl-(Asparagyl)-␤-hydroxylase (AAH) is overexpressed in various malignant neoplasms, including hepatocellular carcinomas (HCCs). The upstream regulation of AAH and its functional role in Notch-mediated signaling and motility in HCC cells was accessed. The mRNA transcript levels of AAH, ins