De Novo Computational Design of Retro-Aldol Enzymes
✍ Scribed by Jiang, Lin (author);Althoff, Eric A. (author);Clemente, Fernando R. (author);Doyle, Lindsey (author);Röthlisberger, Daniela (author);Zanghellini, Alexandre (author);Gallaher, Jasmine L. (author);Betker, Jamie L. (author);Tanaka, Fujie (author);Barbas, Carlos F. (author);Hilvert, Donald (author);Houk, Kendall N. (author);Stoddard, Barry L. (author);Baker, David (author)
- Book ID
- 127230925
- Publisher
- American Association for the Advancement of Science
- Year
- 2008
- Tongue
- English
- Weight
- 629 KB
- Volume
- 319
- Category
- Article
- ISSN
- 0036-8075
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Several new algorithms have been proposed recently for computational de novo ligand design. Empirical scoring functions are now available to prioritize the suggested structures. The first successful applications have been reported.