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DCC: Linking tumour suppressor genes and altered cell surface interactions in cancer?

✍ Scribed by K.R Cho; E.R Fearon


Book ID
116166298
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
748 KB
Volume
31
Category
Article
ISSN
0959-8049

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## Abstract The p16^Ink4^/MTSI/CDKN2 is a cell‐cycle regulatory inhibitor of cyclin‐dependent kinase 4 (cdk4), and a candidate tumour suppressor whose gene on chromosome band 9p21 is frequently deleted or mutated in diverse types of cancer. Cdk4 in association with its D‐type cyclin partners, toget